Acute leukemia with C-G chromosome translocation.

characterized by a specific chromosomal marker (the Philadelphia chromosome, Ph’), a significant percentage of all morphologic types of leukemia, except possibly chronic lymphocytic leukemia, will demonstrate aneuploidy. This report describes the occurrence of acute lymphocytic leukemia (ALL) in a young man with a balanced C-G translocation, t(Cp; Gp+), a rare chromosomal abnormality not previously described in patients with leukemia. The study includes data on the hematologic and cytogenetic status of the patient’s family, one member of which also died of ALL and two members of which demonstrated C-C translocations without leukemia.